SEP-363856 hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

SEP-363856 hydrochloride is an agent of orally active and CNS active psychotropic with a unique, non-D2/5-HT2A mechanism of action, exerts its antipsychotic-like effects, has the potential to treatment of schizophrenia. SEP-856 (10μM) specifically inhibits α2A, α2B, D2, 5-HT1A, 5-HT1B, 5-HT1D, 5-HT2A, 5-HT2B, 5-HT2C and 5-HT7> 50% receptor.

SEP-363856 hydrochloride is an agent of orally active and CNS active psychotropic with a unique, non-D2/5-HT2A mechanism of action, exerts its antipsychotic-like effects, has the potential to treatment of schizophrenia. SEP-856 (10μM) specifically inhibits α2A, α2B, D2, 5-HT1A, 5-HT1B, 5-HT1D, 5-HT2A, 5-HT2B, 5-HT2C and 5-HT7> 50% receptor.SEP-856 (0.3, 1 and 10 mg/kg, i.p.) is CNS active. SEP-856 exhibits a behavioral signature similar to known antipsychotic drugs.PCP-induced hyperactivitysignificantly reduced by SEP-856 (0.3, 1 and 10 mg/kg, orally once) . Oral SEP-856 administration (1, 3 and 10 mg/kg) produces a dosedependent decrease in REM sleep, increase in latency to REM sleep and increase in cumulative wake (W) time.

SEP-856 hydrochloride

Endocrinology/Hormones

5-HT Receptor

5-HT1A Receptor;5-HT1B Receptor;5-HT1D Receptor;5-HT2A Receptor;5-HT2C Receptor;5-HT7 Receptor;TAAR1

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1310422-41-3

219.73

C9H14ClNOS

>98% (HPLC)

DMSO:62.5 mg/mL (284.44 mM; Need ultrasonic)

Cl.CNC[C@@H]1OCCc2ccsc12

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(-20℃)

With Ice Pack

≥ 2 years